ChiroSil® Crown Ether Chiral Stationary Phases

ChiroSil® columns are ideal for the separation of chiral compounds containing primary amines and natural and unnatural amino acids and their derivatives. Chirosil/ME RCA (+) and SCA (-) have (+) or (-)-(18-Crown-6)-tetracarboxylic acid as a chiral selector, which is covalently bonded to the silica support, ensuring excellent column durability. The ChiroSil® CSP is compatible with both normal phase and reversed-phase high-performance liquid chromatography (HPLC) and is available in both analytical and preparative dimensions. It is also available in both enantiomeric forms (RCA (+) or SCA (-)), which allows for inversion of peak elution order, which can be beneficial for preparative separations.

Chirosil Selector Structure

In the case of amino acids, most L-enantiomers elute first on the ChiroSil RCA(+) and D-enantiomers elute first on the ChiroSil SCA(-) column.

In general, the separation factors and resolution factors for analytes on ChiroSil are greater than on ChiroSil ME®, while capacity factors on ChiroSil ME® are greater than on ChiroSil.